Vaccinations & Health Rules for Mozambique: US Citizens 2026

Quick Answer: Vaccines Required vs. Recommended for US Citizens

If you are traveling directly from the United States to Mozambique, no vaccinations are legally required for entry. However, the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Department of State strongly recommend several vaccines based on disease risk in the country.

Vaccine	Entry Requirement (US→MZ)	CDC Recommendation	Timing Before Departure
Yellow Fever	Not required	Not recommended for direct travel	N/A
Hepatitis A	Not required	Recommended for all travelers	2 doses, 6 months apart; 1st dose ≥2 weeks before travel
Typhoid	Not required	Recommended for most travelers	2–3 weeks before departure
Malaria Prophylaxis	Not required	Recommended (medication, not vaccine)	Begin 1–2 days before arrival; continue during & after stay
Routine (MMR, Tdap, Polio)	Not required	Ensure up-to-date	Verify status ≥4 weeks before travel

Last checked July 2026 — always confirm with official sources before travelling.

Yellow Fever Vaccination Certificate: When It's Required

Direct Travel from the United States

You do not need a Yellow Fever vaccination certificate to enter Mozambique if traveling directly from the United States. The U.S. is not classified as a country with risk of Yellow Fever transmission by the World Health Organization (WHO) or Mozambique's health authorities.

Travel via Yellow Fever–Endemic Countries

A valid Yellow Fever vaccination certificate is required if you are:

• Arriving from any country with documented Yellow Fever transmission risk, or
• Transiting through an airport in a Yellow Fever–endemic country for more than 12 hours (even if you don't leave the airport).

Countries with Yellow Fever risk include Angola, Argentina, Benin, Bolivia, Brazil, Burkina Faso, Burundi, Cameroon, Central African Republic, Chad, Colombia, Congo, Côte d'Ivoire, Democratic Republic of Congo, Ecuador, Equatorial Guinea, Ethiopia, French Guyana, Gabon, Gambia, Ghana, Guinea, Guinea-Bissau, Kenya, Liberia, Mali, Mauritania, Nigeria, Panama, Paraguay, Peru, Senegal, Sierra Leone, South Sudan, Sudan, Suriname, Togo, Trinidad and Tobago, Uganda, and Venezuela.

Certificate Validity & Cost if Not Presented

A Yellow Fever vaccination certificate is valid for life as of July 2016; no booster is required. However, it becomes valid for entry 10 days after vaccination.

If you cannot present a valid certificate at the port of entry and one is required, Mozambique will vaccinate you at your own expense, estimated at approximately USD $50.

Recommended Vaccinations for All US Travelers to Mozambique

Hepatitis A

Recommendation: CDC recommends Hepatitis A vaccination for all travelers to Mozambique.

Vaccine schedule:

• Primary series: 2 doses, 6–12 months apart
• First dose: administer ≥2 weeks before travel
• Infants 6–11 months: single dose (does not count toward the routine 2-dose series); also give immune globulin
• If departing in <2 weeks and you are unvaccinated, over 40, immunocompromised, or have chronic medical conditions: receive initial dose plus immune globulin at the same appointment

Risk level: High for all travelers, especially those staying with friends/relatives or visiting smaller cities and rural areas.

Typhoid

Recommendation: CDC recommends Typhoid vaccination for most travelers, particularly those staying outside major tourist hotels or visiting smaller cities and rural areas.

Vaccine options:

• Oral vaccine (Ty21a): 4 doses, 1 every other day; complete series ≥1 week before travel
• Inactivated injection: 1 dose, ≥2 weeks before travel

Confirm availability and specific scheduling with your travel medicine clinic 3–4 weeks before departure.

Routine Vaccinations

Ensure you are up-to-date with age-appropriate routine immunizations before travel:

• Measles, Mumps, Rubella (MMR)
• Tetanus, Diphtheria, Pertussis (Tdap)
• Poliomyelitis (IPV)
• Varicella (Chickenpox)
• Influenza (annual, especially October–April, peak season in Mozambique)
• Pneumococcal (for adults ≥65 or with chronic conditions)

Other Vaccines to Discuss with Your Doctor

Depending on your itinerary, duration, and personal risk factors, your healthcare provider may recommend:

• Hepatitis B: High prevalence in Mozambique; consult your provider
• Rabies: If planning prolonged outdoor activities or animal contact
• Cholera: WHO recommends for unvaccinated travelers ≥1 year old; oral vaccine available
• Chikungunya, Dengue: Mosquito-borne; discuss if extended stay in areas with ongoing transmission

Malaria Prevention: Critical for Mozambique Travel

Risk Level & Geographic Distribution

Malaria is endemic in most areas of Mozambique, including popular safari and beach destinations. There is no malaria vaccine; prevention relies on antimalarial medication and mosquito bite avoidance.

Risk is highest during and shortly after the rainy season (May–August), but transmission occurs year-round in many regions.

Antimalarial Medication

The CDC recommends malaria chemoprophylaxis for travelers to Mozambique. Common options include:

• Atovaquone-proguanil (Malarone): Begin 1–2 days before arrival; take daily during stay; continue 7 days after departure
• Doxycycline: Begin 1–2 days before; take daily; continue 4 weeks after
• Mefloquine (Lariam): Begin 2–3 weeks before; take weekly; continue 4 weeks after
• Primaquine: For specific itineraries; requires G6PD testing first

Consult a travel medicine specialist 4–6 weeks before departure to select the medication best suited to your health profile, itinerary, and duration of stay. Prescriptions cannot be obtained without medical consultation.

Mosquito Bite Prevention

Malaria is transmitted by Anopheles mosquitoes, which bite primarily between dusk and dawn. Reduce risk by:

• Using insect repellent containing DEET (20–30%), picaridin (20%), or oil of lemon eucalyptus on exposed skin
• Wearing long, loose-fitting clothing in light colors at dawn and dusk
• Sleeping under insecticide-treated bed nets, especially in rural areas
• Using air-conditioned or well-screened rooms when available
• Applying permethrin-treated clothing when appropriate

Malaria symptoms can appear 7–30 days after infection, but may emerge up to 1 year after exposure. If you develop fever, chills, or flu-like symptoms during or after travel, seek medical attention immediately and inform your doctor of your travel history.

Health Documents & Travel Insurance

International Vaccination Certificate

If you receive a Yellow Fever vaccination, request an International Certificate of Vaccination or Prophylaxis (ICVP) in English or Portuguese. Keep it with your passport; border authorities may request it.

Travel Insurance with Medical Coverage

Travel insurance that includes medical evacuation and emergency treatment is highly recommended. Mozambique has limited medical facilities outside major cities, and treatment can be expensive. Ensure your policy covers:

• Emergency medical evacuation to South Africa or international facility
• Hospital and clinic visits
• Malaria and dengue treatment
• Repatriation if hospitalized

Medical Documentation

Carry a copy of your vaccination records (digital or printed), any prescriptions for antimalarial medications, and a summary of your medical history in English and Portuguese if possible.

Medications: What You Can Bring & Restrictions

Personal Medications

You may bring prescription and over-the-counter medications for personal use into Mozambique, provided they are:

• In original containers with labels intact
• In reasonable quantities for the duration of your stay
• Accompanied by a copy of the prescription or a doctor's letter (especially for controlled substances)

Medications to Pack

Pharmacies in Mozambique's major cities (Maputo, Beira) stock some medications, but availability is limited and prices are high. Consider bringing:

• Antimalarial medication (prescribed by your doctor)
• Broad-spectrum antibiotic for traveler's diarrhea (prescribed)
• Loperamide (Imodium) for diarrhea
• Antacids and anti-nausea medication
• Antihistamines and decongestants
• Acetaminophen or ibuprofen for pain/fever
• Hydrocortisone cream for insect bites
• First-aid supplies: bandages, antiseptic, tweezers, thermometer
• Sunscreen (SPF 30+) and insect repellent
• Any personal prescription medications in sufficient quantity

Controlled & Restricted Substances

Do not attempt to bring narcotics, psychotropic substances, or large quantities of medications without a prescription and doctor's letter. Penalties for drug violations in Mozambique are severe.

Food, Water & Traveler's Diarrhea Prevention

Food Safety

Foodborne illness is common among travelers to Mozambique. Reduce risk by:

• Eating food that is cooked thoroughly and served hot
• Avoiding raw or undercooked meat, seafood, and eggs
• Peeling fruits and vegetables yourself, or eating only those freshly peeled
• Avoiding street food, buffets, and food left at room temperature
• Eating at established restaurants in tourist areas when possible

Water Safety

Tap water in Mozambique is not reliably safe for drinking or brushing teeth. Use:

• Bottled water (sealed, not refilled locally)
• Boiled water (boil for ≥1 minute at sea level)
• Water purified with iodine tablets or a portable filter
• Beverages made with boiled water (tea, coffee)

Avoid ice, unless made from bottled or boiled water.

Traveler's Diarrhea

Despite precautions, traveler's diarrhea affects many visitors. Ask your doctor to prescribe an antibiotic (e.g., azithromycin or fluoroquinolone) for self-treatment of moderate-to-severe diarrhea. Mild cases often resolve with hydration and over-the-counter remedies.

Health Facilities & Emergency Services in Mozambique

Medical Facilities

Medical facilities in Mozambique are limited, especially outside Maputo and Beira. Private hospitals in major cities offer better care than public facilities but are expensive. Safari lodges and tourist accommodations can usually arrange emergency medical transport.

Major hospitals in Maputo:

• Clinica Maya (private; international standard)
• Hospital Central (public; basic care)
• Clínica Especial (private)

Emergency Contact Information

U.S. Embassy in Maputo (24/7 assistance for U.S. citizens):

• Phone: +258 21 492797 (business hours)
• After-hours emergency: +258 21 490723
• Email: MaputoConsular@state.gov
• Website: mz.usembassy.gov

U.S. State Department Consular Affairs (24/7 from anywhere):

• From abroad: +1-202-501-4444
• From U.S./Canada: +1-888-407-4747

Enroll in the Smart Traveler Enrollment Program (STEP) at travel.state.gov to receive security updates and facilitate emergency assistance.

Hepatitis B & Other Blood-Borne Diseases

Hepatitis B has high prevalence in Mozambique's population. Consider vaccination if you have not previously been immunized, especially if you may have contact with blood or body fluids (healthcare workers, emergency responders, or extended stays).

HIV/AIDS entry restrictions: The U.S. Department of State is unaware of any HIV/AIDS–related entry restrictions for visitors to Mozambique.

Pre-Travel Planning: Timeline & Consultation

4–6 weeks before departure:

• Schedule an appointment with a travel medicine clinic or your primary care physician
• Discuss your itinerary, planned activities, and duration of stay
• Obtain prescriptions for malaria prophylaxis and traveler's diarrhea antibiotics
• Receive recommended vaccines (Hepatitis A, Typhoid)
• Verify routine vaccination status (MMR, Tdap, Polio, Influenza)

2–3 weeks before departure:

• Complete second dose of Hepatitis A (if not yet done)
• Confirm receipt of ICVP if Yellow Fever vaccination was given
• Purchase travel insurance with medical evacuation coverage
• Obtain prescriptions filled and pack medications

1 week before departure:

• Begin malaria prophylaxis if required (1–2 days before arrival)
• Verify all documents: passport, visas (see Mozambique Visa for American Citizens 2026), vaccination records, travel insurance
• Reconfirm health requirements with your airline and the U.S. Embassy in Maputo

Frequently Asked Questions

Do I need a Yellow Fever vaccine to travel from the United States to Mozambique?

No, if you are traveling directly from the United States. A Yellow Fever vaccination certificate is required only if you are arriving from or transiting through a country with Yellow Fever transmission risk (e.g., Brazil, Uganda, Kenya). The U.S. is not classified as a Yellow Fever–endemic country.

What vaccinations does the CDC recommend for Mozambique?

The CDC recommends Hepatitis A, Typhoid, and routine immunizations (MMR, Tdap, Polio, Influenza) for all travelers. Malaria chemoprophylaxis (medication, not a vaccine) is also strongly recommended. Hepatitis B, Rabies, and Cholera may be recommended based on your itinerary and personal risk factors.

How long before travel should I get vaccinated?

Schedule a travel medicine appointment 4–6 weeks before departure. Hepatitis A requires 2 doses, 6 months apart (first dose ≥2 weeks before travel). Typhoid can be given 2–3 weeks before departure. Routine vaccines should be verified ≥4 weeks in advance. Malaria prophylaxis typically begins 1–2 days before arrival.

What is the cost of vaccinations for Mozambique travel?

Vaccination costs vary by clinic and location. Confirm current fees with your travel medicine provider or local health department. Travel insurance may cover some costs. If you arrive without a required Yellow Fever certificate, Mozambique will vaccinate you at your expense (approximately USD $50).

Is malaria a risk in Mozambique, and can I prevent it?

Yes, malaria is endemic in most of Mozambique, including safari and beach destinations. There is no malaria vaccine. Prevention includes antimalarial medication (prescribed by your doctor) and mosquito bite avoidance (insect repellent, long clothing, bed nets, screened rooms). Risk is highest during/after the rainy season (May–August) but occurs year-round.

Can I bring my prescription medications into Mozambique?

Yes, you may bring prescription and over-the-counter medications for personal use in original containers with labels intact. For controlled substances or large quantities, carry a copy of the prescription or a doctor's letter. Pharmacies in Maputo and Beira stock some medications, but availability is limited and prices are high; bring sufficient quantities from home.

What should I do if I develop symptoms of malaria or other illness while in Mozambique?

Seek medical attention immediately. Malaria symptoms (fever, chills, headache, body aches) can appear 7–30 days after infection. Inform your doctor of your travel history. Contact the U.S. Embassy (+258 21 492797 or +258 21 490723 after hours) if you need assistance finding medical care or evacuation.

Do I need travel insurance for a trip to Mozambique?

Yes, travel insurance with medical evacuation and emergency treatment coverage is highly recommended. Medical facilities are limited outside major cities, and treatment is expensive. Ensure your policy covers emergency evacuation, hospital visits, and repatriation if needed.

What is the water situation in Mozambique, and can I drink tap water?

Tap water in Mozambique is not reliably safe for drinking or brushing teeth. Use bottled water (sealed), boiled water, or water purified with iodine tablets or a portable filter. Avoid ice unless made from bottled or boiled water. Foodborne illness is common; eat thoroughly cooked food and avoid raw/undercooked items.

Are there any entry restrictions related to HIV/AIDS in Mozambique?

No, the U.S. Department of State is unaware of any HIV/AIDS–related entry restrictions for visitors to Mozambique.

What health risks should I be aware of beyond vaccines and malaria?

In addition to malaria, be aware of dengue fever, chikungunya, typhoid, cholera, Hepatitis A and B, traveler's diarrhea, and tick-borne illnesses. Food and water precautions, insect bite prevention, and proper hygiene reduce risk. Discuss specific concerns with your travel medicine provider based on your itinerary.

If I'm planning a safari in Mozambique, are there additional health precautions?

Safaris in Mozambique involve outdoor activities in remote areas, increasing exposure to malaria-carrying mosquitoes and other insects. Malaria prophylaxis is essential. Wear protective clothing, use high-concentration insect repellent, and sleep under treated bed nets. Discuss rabies and other wildlife-related risks with your doctor if you plan close animal contact or extended outdoor activities.

Frequently Asked Questions

Do I need a Yellow Fever vaccine to travel from the United States to Mozambique?

No, if you are traveling directly from the United States. A Yellow Fever vaccination certificate is required only if you are arriving from or transiting through a country with Yellow Fever transmission risk (e.g., Brazil, Uganda, Kenya). The U.S. is not classified as a Yellow Fever–endemic country.

What vaccinations does the CDC recommend for Mozambique?

The CDC recommends Hepatitis A, Typhoid, and routine immunizations (MMR, Tdap, Polio, Influenza) for all travelers. Malaria chemoprophylaxis (medication, not a vaccine) is also strongly recommended. Hepatitis B, Rabies, and Cholera may be recommended based on your itinerary and personal risk factors.

How long before travel should I get vaccinated?

Schedule a travel medicine appointment 4–6 weeks before departure. Hepatitis A requires 2 doses, 6 months apart (first dose ≥2 weeks before travel). Typhoid can be given 2–3 weeks before departure. Routine vaccines should be verified ≥4 weeks in advance. Malaria prophylaxis typically begins 1–2 days before arrival.

What is the cost of vaccinations for Mozambique travel?

Vaccination costs vary by clinic and location. Confirm current fees with your travel medicine provider or local health department. Travel insurance may cover some costs. If you arrive without a required Yellow Fever certificate, Mozambique will vaccinate you at your expense (approximately USD $50).

Is malaria a risk in Mozambique, and can I prevent it?

Yes, malaria is endemic in most of Mozambique, including safari and beach destinations. There is no malaria vaccine. Prevention includes antimalarial medication (prescribed by your doctor) and mosquito bite avoidance (insect repellent, long clothing, bed nets, screened rooms). Risk is highest during/after the rainy season (May–August) but occurs year-round.

Can I bring my prescription medications into Mozambique?

Yes, you may bring prescription and over-the-counter medications for personal use in original containers with labels intact. For controlled substances or large quantities, carry a copy of the prescription or a doctor's letter. Pharmacies in Maputo and Beira stock some medications, but availability is limited and prices are high; bring sufficient quantities from home.

What should I do if I develop symptoms of malaria or other illness while in Mozambique?

Seek medical attention immediately. Malaria symptoms (fever, chills, headache, body aches) can appear 7–30 days after infection. Inform your doctor of your travel history. Contact the U.S. Embassy (+258 21 492797 or +258 21 490723 after hours) if you need assistance finding medical care or evacuation.

Do I need travel insurance for a trip to Mozambique?

Yes, travel insurance with medical evacuation and emergency treatment coverage is highly recommended. Medical facilities are limited outside major cities, and treatment is expensive. Ensure your policy covers emergency evacuation, hospital visits, and repatriation if needed.

What is the water situation in Mozambique, and can I drink tap water?

Tap water in Mozambique is not reliably safe for drinking or brushing teeth. Use bottled water (sealed), boiled water, or water purified with iodine tablets or a portable filter. Avoid ice unless made from bottled or boiled water. Foodborne illness is common; eat thoroughly cooked food and avoid raw/undercooked items.

Are there any entry restrictions related to HIV/AIDS in Mozambique?

No, the U.S. Department of State is unaware of any HIV/AIDS–related entry restrictions for visitors to Mozambique.